While not curable, interstitial cystitis may be treated with a variety of medications.
Oral Pentosan Polysulfate (Elmiron)
One oral treatment given is oral pentosan polysulfate (elmiron). This medication may build and restore the protective coating on the bladder epithelium and decrease inflammation with minimal side effects.
Patients suffering from interstitial cystitis may also be given dimethyl sulfoxide into their bladder through a catheter once a week for six weeks. This medication treats the condition by blocking inflammation, decreasing pain and removing tissue-damaging free radicals. Other treatments of interstitial cystitis may include, oral hydroxyzine, oral amitriptyline and the insertion of heparin into the bladder through a catheter.
Oral hydroxyzine is an anti-histamine medication that causes sedation, allowing patients to sleep through the night and urinate less frequently.
Oral amitrptyline is classified as an anti-depressant that also treats interstitial cystitis symptoms. This medication also serves as an anti-histamine, decreases bladder spasms and slows nerves carrying pain messages. Possible side effects with this form of medication are sedation, constipation and weight gain. Heparin placed in the bladder through a catheter works to build and restore the protective coating on the bladder epithelial cells. Side effects are rare.
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