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Peyronie’s Disease

Peyronie’s disease is an abnormal bend of the penis occurring during an erection. The bend develops by plaque accumulating in an area of tissue on the penis. It is estimated that Peyronie’s disease occurs in approximately 1 to 5 percent of men.

The cause of Peyronie’s disease is unclear. For some men, plaque develops following a trauma causing bleeding inside the penis. The trauma may not be noticeable at the time. In other cases, the disease may be genetically linked or inherited.

In severe cases of Peyronie’s disease, hardened plaque reduces the flexibility of the penis, causing pain and forcing it to bend during an erection. While the pain may decrease over time, the bend in the penis remains. Milder forms of Peyronie’s disease can resolve on their own without permanent bending.

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Diagnosis

Peyronie’s disease may be diagnosed during a physical exam where a physician will feel the hardened tissue. A biopsy may also be performed on tissue in the affected area to confirm the diagnosis.

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Treatments

Peyronie’s disease can be successfully treated. Typically, the pain associated with the disease only occurs with an erection and is usually mild. If intercourse is satisfactory then no treatment may be needed. There are several treatment options available for Peyronie’s disease. Surgery will not be recommended for all men with Peyronie’s disease. For the majority of men, the injury will heal over time. This could take up to six to 18 months. In some cases, we may prescribe channel blockers to decrease the pain related to the disease.

Surgery – When surgery is needed it aims to:

• Removal of the plaque on the penis before placing followed by placement of a tissue patch on the affected area.
• Removal or altering the tissue from the side of the penis opposite the plaque, to counter the bending of the penis.

Penile implant surgery is another option for patients with have both Peyronie’s disease and erectile dysfunction. Click here to learn more about penile implant surgery at the Center for Men’s Health at TUCC.

Both microsurgical procedures are performed in the state-of-the-art Urology Surgery Center of Colorado. However, complications such as the shortening of the penis can occur as a result of the surgery. Our physicians will discuss the treatments they believe will be most effective for your case of Peyronie’s disease during your appointment.

Several other treatments are currently being investigated for the treatment of Peyronie’s disease including the injection of medication directly into the plaque on the penis and radiation therapy.

The team at the Center for Men’s Health at TUCC are at the forefront of treating Peyronie’s disease. We served as a clinical trial site for Auxilium Pharmaceuticals’ late-stage study of Xiaflex in 2011 and 2012. This injectable medication was recently approved by the U.S. Food and Drug Administration to go to market. Xiaflex is the first drug to be approved by the FDA for the treatment of Peyronie’s disease.

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